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It is a matter of public record that the loss of tissue and organ functionality is very costly to treat, being estimated at some 350 to 400 billion dollars a year within the US alone, around 8 of total medical spending ( Lysaght and O'Loughlin 2000 ). Such expenditure represents both a significant burden upon the health system and an enormous number of lives affected by serious disease or mortality. The treatment of tissue deficiency is currently constrained, if not by financial implications, b…